Protabit and Caltech Receive DOE Award to Engineer More Efficient Enzyme for Isobutanol Production

February 15, 2014

Protabit has been awarded a DOE Phase I Small Business Technology Transfer (STTR) grant to engineer a more efficient dihydroxyacid dehydratase, a key bottleneck enzyme in the biosynthesis of isobutanol from glucose.  Protabit is partnering with the California Institute of Technology on this 9-month Phase I effort.  The team will apply computational protein design to engineer a cofactor swap, substituting a simple Mg2+ cofactor in place of a complicated, energetically expensive cofactor (Fe-S cluster).

More on this award can be found at