Scientific Advisory Board

Stephen L. Mayo, Ph.D. – Co-Founder

Bren Professor of Biology and Chemistry and Chair of the Division of Biology, California Institute of Technology

Professor Mayo received his Ph.D. in Chemistry from the California Institute of Technology under the direction of Harry Gray. He completed his postdoctoral training as a Miller Fellow at the University of California, Berkeley and with Robert Baldwin at Stanford University. Dr. Mayo is a former Howard Hughes Medical Institute Investigator and a recognized world leader in the development, validation, and application of computational protein design methods. His laboratory at Caltech combines theoretical, computational, and experimental approaches for the study of structural biology, which has led to the development of the computational protein design software packages ORBIT and PHOENIX. In addition to developing new computational tools, his group applies these tools to a variety of protein engineering problems including protein stabilization, enzyme design, small molecule receptors, optimization of the spectral properties of fluorescent proteins, and novel protein-protein interfaces. Professor Mayo was a co-founder of Molecular Simulations, Inc. (currently Accelrys) and Xencor, a protein design company focused on developing improved antibody therapeutics. He has co-authored over 99 refereed papers and was elected to the National Academy of Sciences for his pioneering contributions to the field of protein design.

Brian Kuhlman, Ph.D.

Associate Professor of Biochemistry and Biophysics, University of North Carolina, Chapel Hill

Professor Kuhlman received his Ph.D. in Chemistry from the State University of New York at Stony Brook under the direction of Daniel Raleigh and was a Damon Runyon postdoctoral fellow in the laboratory of David Baker at the University of Washington. He is a recipient of the Feynman Prize in Nanotechnology and the AAAS Newcomb Cleveland Prize. He is currently a W.M. Keck Distinguished Young Scholar in Medical Research. He has co-authored over 65 refereed manuscripts in the field of protein design and folding and is a primary developer of the protein design module for the molecular modeling program Rosetta. His laboratory is focused on developing and testing new methods for de novo protein design, protein interface design, and the design of molecular switches.

Amy Keating, Ph.D.

Associate Professor of Biology, Massachusetts Institute of Technology

Professor Keating received her Ph.D. in Physical Organic Chemistry from UCLA and was a Helen Hay Whitney postdoctoral fellow with Peter Kim and Bruce Tidor at MIT. Work in the Keating laboratory is focused on studying the specificity of protein-protein interactions. A leader in this field, Dr. Keating uses a combined approach that incorporates bioinformatic analysis, structural modeling, computational design, and experimental characterization. Her lab develops new computational and experimental methods and has published more than 39 papers in this area since 2003. Professor Keating currently holds a Director’s Transformative Research award from the NIH to pursue novel strategies for protein interaction modeling and design.

Pamela Bjorkman, Ph.D.

Max Delbrück Professor of Biology, California Institute of Technology

Professor Bjorkman received her Ph.D. in Biochemistry from Harvard University under the direction of Don Wiley. She stayed on in Wiley’s laboratory as a postdoctoral fellow then continued her training with Mark Davis at Stanford University before joining the Biology faculty at Caltech.  She is an investigator of the Howard Hughes Medical Institute and is well known for her pioneering work in structural studies of biological macromolecules. Her research at Caltech focuses on the structure and function of proteins of the immune system, especially interactions involved in immune recognition, and in the structure, function, and therapeutic uses of antibodies and their receptors. Professor Bjorkman has co-authored 149 refereed papers. Among her many awards is election to the National Academy of Sciences, the L’Oreal-UNESCO Women in Science North American Laureate “for her discovery of how the immune system recognizes targets,” and a National Institutes of Health Director’s Pioneer Award.